The Effects of Two Anesthetic Drugs on Some Enzyme Levels in Patients Undergoing Lower Extremity … (NCT05950555) | Clinical Trial Compass
CompletedNot Applicable
The Effects of Two Anesthetic Drugs on Some Enzyme Levels in Patients Undergoing Lower Extremity Surgery
Turkey (Türkiye)90 participantsStarted 2021-12-30
Plain-language summary
The primary aim of this study was to compare the effects of dexmedetomidine and ketamine, which are administered intravenously during surgery, on the levels of malondialdehyde, an antioxidant, anti-inflammatory enzyme, heme oxygenase-1 enzyme levels and C-reactive protein levels in patients who underwent lower extremity surgery under combined spinal epidural anesthesia.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ASA risk classification 1-2
* Patients who agreed to participate in the study
Exclusion Criteria:
* Body mass index (BMI) over 30 kg/m2
* Patients who will use bone cement in the surgical procedure
* Patients who will apply a tourniquet to the lower extremity
* Patients with vascular and coronary disease
* Patients with coagulation disorders that would prevent the application of CSEA
* Patients with allergies to the drugs to be used in the study
* Patients with increased head and intraocular pressure
* Patients with psychiatric and neuromuscular disorders
* Patients with multiple trauma
* Patients who did not consent to participate in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.