Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes

Inclusion Criteria: * Type 1 diabetes for more than five years according to World Health Organization criteria * Age 35-80 years * Hemoglobin A1c \< 80 mmol/mol * Stable insulin therapy (defined as no change in insulin brand and no newly initiated continous subcutaneus insulin infusion (CSII) or multiple-daily injection (MDI) therapy) and, if applicable, stable usage of glucose monitoring technology (e.g., continous glucose monitor (CGM) or intermittently scanned CGM) ≥ 3 months with either MDI or CSII * CRP ≥ 2 mg/L (measured by high-sensitivity assay) * eGFR \> 50 mL/min/L/1.73 m\^2 * Either stable arteriosclerotic cardiovascular disease (ASCVD) (as defined by ischemic heart disease including previous acute myocardial infarction, acute coronary syndrome and coronary revascularization; other arterial revascularization procedures; stroke and transient ischemic attack; aortic aneurysm; peripheral arterial disease, including carotid atherosclerosis) * and/or risk of cardiovascular (CV) death \> 5 % within 10 years (i.e., high or very high CV risk) as defined by the European Society of Cardiology or 10-year CV risk ≥ 20 % (i.e., high CV risk) as according to 'Steno Type 1 Diabetes Risk Engine' (https://steno.shinyapps.io/T1RiskEngine/) Exclusion Criteria: * Hypoglycemia unawareness (inability to register low blood glucose) am modum Pedersen-Bjergaard, unless usage of CGM with alarm function * Liver disease with elevated plasma alanine aminotransferase (ALT) \> three times the…