The goal of this clinical trial is to evaluate the safety and tolerability of multiple doses of human umbilical cord mesenchymal stem cell injection in patients with decompensated hepatitis B cirrhosis, and to further explore the efficacy, pharmacodynamic profile and appropriate dose of administration to provide a basis for the use of safer and more effective treatments for patients with decompensated hepatitis B cirrhosis in the future. Participants are required to sign an informed consent form and, after undergoing a series of tests and meeting the protocol's entry and exclusion criteria, are assigned to a dose group for intravenous infusion of human umbilical cord mesenchymal stem cells.
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Adverse Event (AE)
Timeframe: Through study completion, an average of 1 year
Serious Adverse Event (SAE)
Timeframe: Through study completion, an average of 1 year
Recommended dose for phase 2 clinical trial (RP2D)
Timeframe: Through study completion, an average of 1 year
Dose-limiting toxicity (DLT)
Timeframe: Through study completion, an average of 1 year
Maximum Tolerated Dose (MTD)
Timeframe: Through study completion, an average of 1 year