CompletedPhase 4

The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.

Egypt120 participantsStarted 2023-05-25

Plain-language summary

The aim of our study to compare two different doses of Dexmedetomidine added to anesthetic dose of ketamine in the induction of general anesthesia in adult patients regarding the hemodynamic profile, adequacy of hypnosis, intubation conditions and recovery type. We hypothesize that the use of Ketodex during induction of general anesthesia will produce better control regarding the hemodynamic profiles and quality of intubation than propofol.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: \- All patients undergoing elective general surgery. Patients aged \>18 years. ASA I and II. Both sexes. Exclusion Criteria: * All patients undergoing emergency surgery. Patients less than 18 years. History of difficult intubation, abnormal airway examination Cardiac morbidities (impaired contractility with ejection fraction \< 50%, heart block, arrhythmias, tight valvular lesions). Patients on angiotensin converting enzyme inhibitors and angiotensin receptor blockers medications. Patients with uncontrolled hypertension. Patients with allergy of any of the study drugs. Body mass index \> 35 kg/m2

What they're measuring

Incidence of post-induction hypotension

Timeframe: the first 20 min after general anaesthesia induction.

Trial details

NCT IDNCT05948267

SponsorKasr El Aini Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-10-30

View on ClinicalTrials.gov More The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability trials