A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps

Inclusion Criteria: * Bilateral polyps in nose and sinuses * ESS within the last three years (unless unfit for surgery y- in this study defined as either a severe somatic disease, for which other specialist advise against surgery, e.g., cardiac disease, pulmonary disease, or coagulation disorder OR/AND severe anxiety which can either be due to previous traumatic experiences with surgery or the postoperative period, post-traumatic stress disorder or severe anxiety disorder. In cases of doubt, investigators can ask for a written statement from the general practitioner or a psychiatrists/psychologist)) * Optimal local treatment with saline irrigation and topical nasal steroids for at least three months (unless contraindicated) * Evidence of type 2 inflammation Furthermore, patients must fulfil three out the following five criteria: * Need for systemic corticosteroids (at least two courses/year OR long-term treatment \>3 months) or contraindication to systemic steroids * Significantly impaired QoL (SNOT-22 score≥50) * Significant LoS (SSIT-16 score 0-8) * NPS ≥5 (with at least 2 on either side) * Asthma diagnosis (requiring inhaled corticosteroid (ICS)) Also: Age of 18 years or more and able to read and/or speak Danish Exclusion criteria * Systemic corticosteroid treatment within the last three months * Endoscopic sinus surgery (ESS) within the last six months * Non-adherent to medicine regimens * Hypersensitivity to the active substance or any of the excipients in the two …