The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients

Inclusion Criteria: * Signed and dated written informed consent. * Patients aged ≥18 years with KTR * \>3 months post kidney transplantation * Estimated glomerular filtration rate \[eGFR\] ≥20 ml/min/1.73m2 * BP \<160/100 and \>90/60 at screening * Body-mass index \[BMI\] between 18.5-40kg/m2 * In patients with T2D or PTDM, HbA1c \<12.0%; Exclusion Criteria: * Type 1 diabetes. * History of multi-organ transplant * Acute coronary syndrome, transient ischemic attack or stroke within 30 days prior to screening * Impending need for kidney biopsy or rapid decline in eGFR within 30 days prior to screening * Actively treated BK, CMV or EBV infection * Recurrent pyelonephritis or need for indwelling or self-catheterization * Prior amputation or ischemic rest pain * Women who are pregnant, nursing, or who plan to become pregnant whilst in the trial. * History of pancreatitis * Personal or family history or medullary thyroid cancer or MEN2B * History of unstable diabetic retinopathy within 1 year prior to screening * Use of SGLT2i or GLP-1RA within 30 days prior to screening. * Current and frequent episodes of hypoglycemia * Current history of DKA requiring medical intervention or hospitalization * With current risk of volume depletion, hypotension and/or electrolyte imbalance * With known or suspected hypersensitivity to semaglutide or related products * Patient not able to understand and comply with study requirements, based on Investigator's judgment. * Any other clinical conditi…