First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects
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Number of participants with treatment emergent adverse events (TEAEs), adverse events of special interests (AESIs), and serious adverse events (SAEs)
Timeframe: Part A (SAD): Up to 105 days; Part B (MAD): Up to 174 days
Percentages of participants with TEAEs, AESIs, and SAEs
Timeframe: Part A (SAD): Up to 105 days; Part B (MAD): Up to 174 days
The Number of Clinically Significant Changes from Baseline in Clinical Laboratory Tests Reported as AE
Timeframe: Baseline and up to 69 days
Number of participants with vital signs out of normal range
Timeframe: Baseline and up to 69 days
Change from Baseline in corrected QT interval using Fridericia's formula (QTcF) values of triplicate electrocardiograms
Timeframe: Baseline and up to 69 days
Absolute values of QTcF on electrocardiograms
Timeframe: Baseline and up to 69 days
Number of participants with abnormal electrocardiogram findings
Timeframe: Baseline and up to 69 days