ABSORB (Amount of Blueberries So Older Adults Reap Benefits) (NCT05937165) | Clinical Trial Compass
CompletedNot Applicable
ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
United States6 participantsStarted 2023-10-31
Plain-language summary
This randomized, cross-over, pilot study aims to compare preliminary impact of a standard dose of blueberry powder (24 g) vs a higher dose (48 g) on the bioavailability of flavonoids and inflammatory biomarkers in older adults with minor levels of depressive symptoms.
Who can participate
Age range65 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Men and women aged 65 years and older
* Minor levels of depressive symptoms (center for epidemiological studies depression scale, ≥4 and \<16 points)
Exclusion Criteria\*:
* Unwilling to follow the study protocol
* Cognitive impairment (assessed via the telephone Montreal Cognitive Assessment) defined as individuals scoring \<19)
* Self-reporting a history of major depression, bipolar, schizophrenia, or other psychotic or neurologic disorders
* Self-reporting of history gastro-intestinal diseases/conditions e.g., of bowel resection, inflammatory bowel disease/syndrome, Celiac disease
* Self-reporting immune disorders, e.g., rheumatoid arthritis, cancer, and other immunocompromising conditions
* Self-reporting history of type 1 or type 2 diabetes
* Self-reporting any history of substance or alcohol use disorder
* Allergy to blueberries
* Self-reporting use of anti-inflammatory (e.g., fish oil or non-steroidal anti-inflammatory drugs) or immune-suppressant drugs
* Are excessive tea or coffee consumers (e.g., \>3 cups/day)
* Recent and consistent use of antibiotics
* Currently taking or advised during the intervention to take anti-depressants
* Current homicidal or suicidal ideation (assessed via the P4 Suicidality Screener
* All deviations must be approved by the study sponsor