Clinical Trial of Cross-linked Hyaluronic Acid Dermal Filler

Inclusion Criteria: * Subjects are aged 18-65 years old of both sexes. * Subjects who are willing to undergo both sides nasolabial fold therapy. * The baseline measurement on the wrinkle severity rating scale (WSRS) should be 3-4 points, and the left and right sides should exhibit symmetry. * Willing to comply with re-visit schedule and sign the informed consent. Exclusion Criteria: * Women subjects who are pregnant, breastfeeding, planning to become pregnant, and not willing to take contraception during the trial period. * Those who are emotionally unstable or suffering from a mental disease. * Those who have unhealthy facial skin or severe skin disease, inflammation, or related symptoms such as infections, psoriasis, herpes, and similar conditions. * Those with any disease that would interfere the assessment of skin aging. * Those who have a scar in the nasolabial fold area. * Those with connective tissue diseases. * Those with diabetes or systemic disease that cannot be controlled. * Those suffering from immunity related disorder. * Those with a scar-prone constitution. * Patients undergoing anticoagulant treatment, those who have a medical history of coagulation defects. * Patients taking antiplatelet medicine that could affect platelet function, such as Aspirin or non-steroidal anti-inflammatory analgesics. * Those with a allergy history of cosmetic filling agent, any type of hyaluronic acid implants or local anesthetic. * Those who have undergone facial cosmetic trea…