The purpose of this clinical study is to evaluate the immunogenicity and immunopersistence of the ACYW135 meningococcal polysaccharide conjugate vaccine (CRM197 vector).The protocol consists of two parts: Part 1 enrolled 660 eligible participants aged 6 to 23 months, which has now been completed. Part 2 : Open Clinical Researchplans to enroll approximately 100 eligible participants from Part 1 who have completed immunopreservance blood sampling. Participants will receive a single booster dose of the ACYW135 group meningococcal polysaccharide conjugate vaccine (CRM197 vector) at age 3 years (but not yet 4 years).
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Antibody positivity for A, C, Y and W135 in all subjects 6 months after 2 dose exemption
Timeframe: 6 months after 2 dose exemption
Seroconversion rates for serotypes A, C, Y, and W135
Timeframe: 30 days post-booster vaccination
Geometric mean titers (GMTs) for serotypes A, C, Y, and W135
Timeframe: 30 days post-booster vaccination
Increased incidence of adverse reactions
Timeframe: Within 7 days after post-booster vaccination