Feasibility Study: tDCS for Treatment of Refractory Status Epilepticus

Inclusion Criteria: * Patient with refractory status epilepticus (RSE), or supra-refractory status epilepticus (SRSE), or electroencephalographic (EEG) characteristics \> 50% of the time on the ictal-interictal continuum (IIC) or epilepsia partialis continua for at least 12 hours. * A patient with RSE is defined as having seizure(s) refractory to first line benzodiazepines and second-line antiseizure medications (ASMs; phenytoin, levetiracetam, valproate). * A patient with SRSE is defined as: * requiring at least 24 hours of a third-line intravenous anesthetic therapy (IVAT) such as propofol, midazolam, or ketamine, and * failing at least one previous wean of an IVAT. * A patient with epilepsia partialis continua (EPC) is defined as: * having focal seizure(s) refractory to first line benzodiazepines and second-line ASMs and * repeated episodes lasting more than one hour * A patient on the IIC is defined as: * having periodic discharges or rhythmic patterns at a rate at more than 1Hz and less than 3Hz and * IIC patterns for more than 50% of the time (IIC burden = 50%) within any prior 12 hour interval. * access to continuous EEG monitoring * brain imaging (Computerized Tomography or Magnetic Resonance Imaging) within 1 year of presentation Exclusion Criteria: * Damaged skin on scalp as determined by the primary team that prevents reasonably accurate electroencephalography monitoring and which may interfere with tDCS stimulation. * Cranial…