Between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year. Sun protection continues to be a major public health issue and has always been a priority research area for Pierre Fabre laboratories. The involvement of ultraviolet radiation of the solar spectrum in skin carcinogenesis is well known, through its ability to damage the DNA of skin cells and the induction of oxidative processes. The aim of this exploratory study is to perform the quantification of: * DNA photoproducts excised from the genome by the biological repair systems in urine samples * cellular DNA damage in the epidermis following chronic exposure to natural sunlight. This study will allow us to better understand and quantify the benefit of sunscreens on photoinduced cellular damage and their elimination in urine.
Age range
18 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in photoinduced DNA damage products in urine samples before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (occuring between day 7 to 39 depending on the duration of sun exposure)
Number of CPD (Cyclobutane Pyrimidine Dimer) lesions in epidermal samples collected from the forearm following the outdoor sun exposure period
Timeframe: Day 7 to 39 (depending on the duration of sun exposure)
Change in colorimetric parameters before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure)
Change in pigmentation parameters before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure)
Change in cellular damages before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure) up to visit 3 ( between day 20 to 56)