Between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year. Sun protection continues to be a major public health issue and has always been a priority research area for Pierre Fabre laboratories. The involvement of ultraviolet radiation of the solar spectrum in skin carcinogenesis is well known, through its ability to damage the DNA of skin cells and the induction of oxidative processes. The aim of this exploratory study is to perform the quantification of: * DNA photoproducts excised from the genome by the biological repair systems in urine samples * cellular DNA damage in the epidermis following chronic exposure to natural sunlight. This study will allow us to better understand and quantify the benefit of sunscreens on photoinduced cellular damage and their elimination in urine.
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Change in photoinduced DNA damage products in urine samples before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (occuring between day 7 to 39 depending on the duration of sun exposure)
Number of CPD (Cyclobutane Pyrimidine Dimer) lesions in epidermal samples collected from the forearm following the outdoor sun exposure period
Timeframe: Day 7 to 39 (depending on the duration of sun exposure)
Change in colorimetric parameters before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure)
Change in pigmentation parameters before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure)
Change in cellular damages before and after outdoor sun exposure
Timeframe: Change from baseline (day 1) to visit 2 (between day 7 to 39 depending on the duration of sun exposure) up to visit 3 ( between day 20 to 56)