Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality (NCT05925322) | Clinical Trial Compass
RecruitingNot Applicable
Brain Changes During Social Reward Psychotherapy for Mid- and Late-Life Suicidality
United States128 participantsStarted 2023-09-18
Plain-language summary
The investigators hypothesized that during the 9-week course of Engage \& Connect treatment there will be an increase in brain functions of the Positive Valence System which in turn will lead to reduction in suicidality.
Who can participate
Age range50 Years – 80 Years
SexALL
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Inclusion Criteria:
* Ages aged 50-80 \[stratified so that 50% are older than 65\]
* Endorsement of Suicidal Ideation \[Structured Clinical Interview for the Diagnostic and Statistical Manual for Mental Disorders-5 (SCID-5) Suicide Item (Item 9) with a score of 2
* Major Depressive Disorder as determined by the SCID-5
* Depression Rating Scale \[Montgomery-Ã…sberg Depression Rating Scale (MADRS)\] score of 16 or greater.
* Mini Mental Status Exam (MMSE) equal or greater than a score of 23
* Off antidepressants or on a stable dose of an antidepressant for 8 weeks and do not intend to change the dose in the next 10 weeks, without individual psychotherapy services during the study period.
* Capacity to provide consent for research assessment and treatment.
Exclusion Criteria:
* Intent or plan to attempt suicide in the near future.
* History or presence of psychiatric diagnoses other than major depressive disorder without psychotic features, generalized anxiety disorder, or specific phobia.
* Use of psychotropic drugs or cholinesterase inhibitors other than use of 0.5 mg or less of lorazepam daily up to seven times per week.
* Neurological disorders (dementias, amnestic and multidomain Mild Cognitive Impairment, Parkinson's disease, epilepsy, etc.).
* Acute or severe medical illness in the past 3 months (metastatic cancer, multiple sclerosis, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction, cardiac, renal, or respiratory failure; s…
What they're measuring
1
Change in resting state functional connectivity of the Positive Valence System
Timeframe: Baseline, midtreatment (week 6) and post treatment (week 9)
2
Change in STAR task reaction time following social feedback
Timeframe: Baseline, midtreatment (week 6), and post treatment (week 9)
Trial details
NCT IDNCT05925322
SponsorWeill Medical College of Cornell University