CompletedPhase 4

Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound Infections

United States1,398 participantsStarted 2023-10-09

Plain-language summary

This will be a single-center randomized control trial comparing the efficacy of two different formulations of Chlorhexidine surgical skin preparation in preventing cesarean section wound infections. Participants will be randomized to either 4% Chlorhexidine Gluconate aqueous solution (CHG) or 2% Chlorhexidine with isopropyl alcohol (CHG-IPA) 70% to examine the risk of infectious morbidity in those undergoing cesarean delivery. There will also be a cost-effectiveness analysis of the two preoperative skin preparations.

Who can participate

Age range18 Years – 50 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Women undergoing cesarean delivery at Magee Women's Hospital Exclusion Criteria: * Inability to obtain consent (language barrier, emergency cesarean section etc.) * Allergy to chlorhexidine or alcohol * Chorioamnionitis * Emergency cesareans where cannot wait for chlorhexidine alcohol to dry * bowel injury at time of cesarean section * Women who are delivered at another institution and are transferred postpartum to Magees Women's Hospital

What they're measuring

Number of Participants with Surgical site Infection

Timeframe: Within 30 days post cesarean

Trial details

NCT IDNCT05920122

SponsorHyagriv Simhan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-17

View on ClinicalTrials.gov More Surgical Site Infection trials