The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excreti… (NCT05919810) | Clinical Trial Compass
CompletedNot Applicable
The Effects of Oral Probiotics and Herbal Supplementation on the Gut Microbiome and Sebum Excretion Rate in Non-Cystic Acne
United States36 participantsStarted 2023-07-03
Plain-language summary
The purpose of this study is to evaluates how probiotics and dietary supplementation with an herbal powder can shift the gut microbiome in those with non-cystic acne vulgaris.
Who can participate
Age range12 Years – 45 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Subjects 12 years of age until 45 years of age
* The presence of mild to moderate acne based on investigator global assessment.
* Presence of at least 10 inflammatory lesions and at least 5 non-inflammatory lesions
Exclusion Criteria:
* The presence of severe acne as noted by the investigator global assessment.
* Those who are unwilling to discontinue oral probiotic-based supplementation, or supplement ingredients found in the study's oral product 1 month prior to enrollment.
* Those who are unwilling to discontinue topical antibiotics and topical benzoyl peroxide for 2 weeks prior to enrollment
* Those who are unwilling to keep their facial regimen the same throughout the study
* Individuals who have been on an oral antibiotic for acne within the previous one month.
* Individuals who are pregnant or breastfeeding.
* Individuals who have changed any of their hormonal based contraception or therapies within 3 months prior to joining the study.
* Individuals on oral contraceptive pills or progesterone or estrogen containing therapies
* Use of isotretinoin within the three months prior to enrollment.
* Individuals on finasteride or dutasteride
* Current tobacco smoker or a tobacco smoking history
What they're measuring
1
Gut microbiome composition of short chain fatty acid producing bacteria