Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Inclusion Criteria: * Moderately to severely active CD as defined by CDAI and SES-CD, assessed by central read * Elevated very soft or liquid stool frequency and/or abdominal pain * Must have no response, insufficient response, loss of response and/or intolerance to at least 1 conventional therapy (e.g. corticosteroids) or advanced therapy Exclusion Criteria: * Diagnosis of ulcerative colitis, indeterminate colitis, microscopic colitis, ischemic colitis, infectious colitis, radiation colitis or active diverticular disease * Short gut syndrome * Presence of an ostomy or ileoanal pouch * Bowel resection or diversion with \~6-months