Poor bone health is a well-recognized but poorly understood complication in children with intestinal failure (IF) who are dependent on parenteral nutrition (PN). Previously, we showed that children with IF have decreased bone turnover markers. It is currently unknown if optimization of parenteral nutrition is related to improved bone turnover markers. Serum concentrations of bone markers (osteocalcin, bone-specific alkaline phosphatase and c-telopeptide) will be measured in 30 IF patients treated at a multidisciplinary intestinal rehabilitation and home PN program at the Hospital for Sick Children and compared to bone markers in 30 age- and sex-matched healthy controls.
Age range
6 Weeks – 18 Years
Sex
ALL
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Bone turnover markers - Osteocalcin
Timeframe: Baseline
Bone turnover markers - C-telopeptide
Timeframe: Baseline
Bone turnover markers - Bone-specific alkaline phosphatase
Timeframe: Baseline