Efficacy and Safety of Surufatinib Combined With Gemcitabine and Albumin-bound Paclitaxel in the Peri-operative Treatment of Pancreatic Cancer

Inclusion Criteria: * Histologically or cytologically confirmed high-risk resectable or borderline resectable pancreatic cancer; * 18-75 years old (including 18 and 75 years old); * No BRCA1/2 or PALB2 mutation; * No previous systematic treatment or radiotherapy; * Eastern Cooperation Oncology Group (ECOG) performance status of 0-1; * Life expectancy ≥ 6 months; * At least one measurable lesion according to RECIST version 1.1; * Adequate organ and bone marrow functions: -Absolute neutrophil count≥1.5x10\^9/L; -Platelet count≥100x10\^9/L; -Hemoglobin≥9g/dL; -Serum bilirubin≤1.5x the upper limit of normal (ULN); -Alanine aminotransferase (ALT) and aspartate aminotransferase (AST)≤2.5x ULN; -Serum creatinine≤1.5x ULN or endogenous creatinine clearance rate ≥ 60ml / min; -INR≤1.5×ULN, PT and APTT≤1.5×ULN； * Women of childbearing age need to take effective contraceptive measures. Exclusion Criteria: * With distant metastasis; * Have received blood transfusion treatment, blood products and hematopoietic factors, such as albumin and granulocyte colony-stimulating factor (G-CSF) within 14 days before enrollment; * Have received any surgery or invasive treatment or operation within 4 weeks before enrollment (except venous catheterization, puncture and drainage, etc.); * Allergic to the study drug or any of its adjuvants; * researchers judged clinically significant electrolyte abnormalities; * History of serious cardiovascular and cerebrovascular diseases: -Cerebrovascular accident …