Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion (NCT05903560) | Clinical Trial Compass
RecruitingNot Applicable
Radial Versus Femoral Access For Thrombectomy in Patients With Acute Basilar Artery Occlusion
China386 participantsStarted 2023-07-22
Plain-language summary
Stroke is one of the most important diseases endangering the health and quality of life of Chinese people. Acute ischemic stroke (AIS) is commonly caused by cerebrovascular stenosis or occlusion. The most effective treatment for AIS is timely and successful angiographic reperfusion.
Due to the large diameter and obvious positioning of bilateral femoral arteries, the transfemoral artery (TFA) using Seldinger's technique has been the most commonly used approach for endovascular treatment. However, recent studies have suggested that the radial artery is an ideal puncture site for cerebrovascular intervention. Small sample studies have confirmed that endovascular recanalization for acute anterior circulation large vessel occlusion via TRA has been safe and effective. Still, there are some complex approaches needed to be converted to TFA. There has been no difference in total operation duration and fluoroscopy time between TRA and TFA, but the TRA group had higher radiation dose and shorter hospital stays than the TFA group. In addition, TRA tends to be more convenient than TFA, especially for posterior circulation lesions.
However, the current studies are based on a single center with a small sample size, and there has been still a lack of large-sample randomized controlled experiments to verify the safety and effectiveness of posterior endovascular recanalization via TRA.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Acute ischemic stroke in the posterior circulation confirmed by symptoms and imaging examinations.
✓. Basilar artery occlusion confirmed by computed tomographic angiography (CTA), magnetic resonance angiography (MRA), or digital subtraction angiography (DSA).
✓. Age ≥ 18 years.
✓. Time from symptom onset to randomization within 24 hours of the estimated time of basilar artery occlusion.
✓. Baseline NIHSS score ≥ 10 before randomization.
✓. Intact dual circulation of the hand assessed by the modified Allen's test.
✓. Written informed consent from patients or their legally authorized representatives.
Exclusion criteria
✕. Pre-stroke disability with mRS score ≥ 3.
✕. Pregnant or lactating women.
✕. Allergic to contrast agents or nitinol devices.
What they're measuring
1
The proportion of favorable neurological function at 90 days (defined as mRS score ≤ 3)