Air Cold Atmospheric Pressure Plasma Treatment for Acceleration of Venous Ulcer Healing

Inclusion Criteria: * Be of legal age (18 years). * Signed informed consent. * Presenting at least one venous ulcer larger than 1 cm2 that has not healed in the last 3 weeks from its appearance. * Absence of surgical indication for ulcer coverage by skin graft. Exclusion Criteria: * Uncontrolled diabetes mellitus (HbA1c \> 8%). If during the trial the patient suffers a decompensation of diabetes, it will be considered an adverse event. * Patient allergic to silver or any other material that will be used during the cure of the ulcer under study. * Concomitant treatment with vacuum-assisted closure (VAC) therapy. * Use of topical antibiotic therapy. The minimum washing time should be 48 hours. * Presence of critical limb ischemia defined as an ankle-brachial index (ABI) below 0.5 or a transcutaneous O2 pressure (TcPO2) below 15 mmHg. * Treatment with corticosteroids in the 14 days prior to the study or with other immunosuppressants. * Presence of a chronic or active skin disorder that may negatively influence wound healing (such as Marfan or Ehlers-Danlos syndrome, systemic lupus erythematosus, systemic sclerosis, or psoriasis). * Pregnancy or lactation. * Advanced or metastatic stage cancer. * Deficiency states. * Dementia. * Post radiation wounds. * Sepsis.