Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women (NCT05889598) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
United Kingdom110 participantsStarted 2022-03-01
Plain-language summary
Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older. Aging is also associated with sarcopenia, the progressive loss of muscle strength and mass with age. In this three-arm study, the effect of resistance exercise programs with different parameters (such as velocity and load) on various outcomes, including structural changes (bone mineral density, cartilage composition, muscle size), physical function, and biomarkers will be compared.
Who can participate
Age range50 Years – 70 Years
SexFEMALE
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Inclusion Criteria:
* Women between 50-70 years;
* Experienced last menstrual cycle, hormonal contraception or menopausal hormone replacement therapy at least five years ago;
* Independent living and able to come into the university;
* Healthy women: not previously diagnosed with osteoporosis or knee osteoarthritis, other major medical conditions;
* Able to understand English.
Exclusion Criteria:
* Any existing symptomatic knee, hip, back injury or any medical conditions or injuries which would affect the ability or safety to perform exercise or influence bone/cartilage, including unstable angina, uncontrolled hypertension, a history of heart failure, and a history of cardiovascular disease and conditions;
* Taking medication affecting bone/cartilage metabolism;
* Regular (\>once per week on average) participation in resistance training with loading greater than bodyweight or in high impact (impact greater than jogging);
* Blood pressure exceeding 150/90 mmHg;
* BMI \> 30 kg/m2;
* Contraindications to MRI or DXA (e.g. Metallic implants);
* Osteoporotic (FRAX score according to which the participant would be advised to seek treatment);
* Fracture within the past year.
What they're measuring
1
Change in Femoral neck bone mineral content from baseline
Timeframe: 32nd week
2
Change in Femoral neck bone mineral density from baseline