Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women (NCT05889598) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
United Kingdom110 participantsStarted 2022-03-01
Plain-language summary
Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older. Aging is also associated with sarcopenia, the progressive loss of muscle strength and mass with age. In this three-arm study, the effect of resistance exercise programs with different parameters (such as velocity and load) on various outcomes, including structural changes (bone mineral density, cartilage composition, muscle size), physical function, and biomarkers will be compared.
Who can participate
Age range
50 Years – 70 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women between 50-70 years;
* Experienced last menstrual cycle, hormonal contraception or menopausal hormone replacement therapy at least five years ago;
* Independent living and able to come into the university;
* Healthy women: not previously diagnosed with osteoporosis or knee osteoarthritis, other major medical conditions;
* Able to understand English.
Exclusion Criteria:
* Any existing symptomatic knee, hip, back injury or any medical conditions or injuries which would affect the ability or safety to perform exercise or influence bone/cartilage, including unstable angina, uncontrolled hypertension, a history of heart failure, and a history of cardiovascular disease and conditions;
* Taking medication affecting bone/cartilage metabolism;
* Regular (\>once per week on average) participation in resistance training with loading greater than bodyweight or in high impact (impact greater than jogging);
* Blood pressure exceeding 150/90 mmHg;
* BMI \> 30 kg/m2;
* Contraindications to MRI or DXA (e.g. Metallic implants);
* Osteoporotic (FRAX score according to which the participant would be advised to seek treatment);
* Fracture within the past year.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Femoral neck bone mineral content from baseline
Timeframe: 32nd week
2
Change in Femoral neck bone mineral density from baseline