High concentrations of parathyroid hormone (PTH) are common in patients with hepatocellular carcinoma (HCC). This study is aimed to investigate effects of vitamin D status and its multiple mega-dosage supplementation on PTH and clinical outcomes in HCC patients before and after hepatectomy. It's a single-center, prospective, parallel, double-blind, placebo-controlled study for 120 eligible subjects. The subjects will receive consecutively 3-day intervention treatments from 7th day before surgery. 30-day postoperative mortality, postoperative complications, and laboratory data will be evaluated.
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Whether there is an association between 25(OH)D and PTH: positive or negative association , or no association
Timeframe: During the study period
Ratio of liver failure
Timeframe: 7 days pre- OP (day -7)
Ratio of liver failure
Timeframe: 1 day pre- OP (day -1)
Ratio of liver failure
Timeframe: 1 day post- OP (day 1)
Ratio of liver failure
Timeframe: 1 day before discharge