The goal of this clinical trial is to evaluate the effect of a time-restricted eating (TRE) regimen on hallmarks of aging, in comparison with traditional caloric restriction and an unrestricted diet in adults with overweight/obesity. Investigators aim to assess: 1. If TRE is sustainable over 6-months. 2. If TRE positively affects metabolism and body composition 3. If TRE improves circadian rhythm/sleep. 4. If TRE benefits cognitive function, mood and quality of life (QoL). 5. If these beneficial effects are associated with changes in molecular hallmarks of aging. Participants will be randomly allocated to: * an unrestricted Mediterranean diet group (MedD) * a energy-reduced Mediterranean diet group (MedD\_RC) * or to an unrestricted Mediterranean diet with TRE group (MedD\_TRE) Intervention will be maintained for 6 months, and there will be an additional 6-months period of follow-up to assess the maintenance of the intervention without supervision. Changes from baseline in phenotypic and molecular hallmarks of aging, including: chronobiology, quality of life, cognition, metabolism and epigenetics among groups over the follow-up will be analyzed.
Age range
55 Years – 70 Years
Sex
ALL
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Change from baseline in participant's meal timing measured by questionnaires.
Timeframe: 12 months
Change from baseline in participant's postprandial glucose levels
Timeframe: 12 months
Change from baseline in fat mass measured by bioimpedance
Timeframe: 12 months
Change from baseline in muscle mass measured by bioimpedance
Timeframe: 12 months
Change from baseline in the blood concentration of metabolites as measured by MNR
Timeframe: 12 months
Change from baseline in chronotype assessed by the morningness/eveningness (MEQ)questionnaire
Timeframe: 12 months
Change from baseline in sleep quality as measured with the Pittsburg's questionnaire
Timeframe: 12 months
Changes form baseline in cognitive function scores measured by the Rey Auditory Verbal Learning Test (RAVLT).
Timeframe: 12 months
Changes form baseline in cognitive function scores measured by STROOP color and Word test.
Timeframe: 12 months
Changes from baseline in the Emotional Eating Questionnaire.
Timeframe: 12 months
Changes from baseline in anxiety scores measured by the Hamilton Anxiety Rating Scale
Timeframe: 12 months
Changes from baseline in mood scores measured by the EVEA Scale for Mood Assessment.
Timeframe: 12 months
Changes from baseline in health-related quality of life measured by the SF-36 questionnaire
Timeframe: 12 months
Changes from baseline in well-being measured by the W-BQ12 questionnaire.
Timeframe: 12 months
Changes from baseline in the accumulation of autophagy vacuoles
Timeframe: 12 months
Changes from baseline in biological age measured by the Horvath's DNAmPhenoage algorithm
Timeframe: 12 months
Changes from baseline in the percentage of senescent T cells
Timeframe: 12 months