Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRD

Inclusion Criteria: * The patients who met the clinical diagnostic criteria for LPRD (by asking history and laryngoscopy, RSI score \>13 or RFS score \>7 points); * No antacids or gastrointestinal motility drugs were taken within 2 weeks before enrollment. * Be aged 18-65 years with no gender restriction; * Patients understood and agreed to participate in this study and signed an informed consent form. Exclusion Criteria: * complicated with acute upper respiratory tract infection; * combined with one of the following diseases of the digestive system: peptic ulcer, history of gastroesophageal and duodenal surgery, Zollinger-Ellison syndrome, pyloric obstruction, primary esophageal motility disorders (e.g., achalasia, scleroderma, primary esophageal spasm), drug-induced esophagitis, mycotic esophagitis, gastrointestinal malignant tumor; * patients with severe primary diseases of heart, brain, liver, lung, kidney, blood and endocrine system, and severe psychosis without effective control; * those who could not take medicine during pregnancy or lactation, or who were allergic to the drugs used in this study; Or unable to cooperate with medication and complete relevant records due to various circumstances; * patients who have participated or are participating in other drug clinical trials within three months; * patients judged by the investigator to be ineligible for trial participation.