The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis (NCT05878873) | Clinical Trial Compass
CompletedNot Applicable
The Neural Mechanisms of Split-belt Treadmill Adaptation in People With Multiple Sclerosis
United States51 participantsStarted 2023-11-28
Plain-language summary
Majority of people with multiple sclerosis experience difficulty with balance and mobility, leading to an increased risk of falls. The goal of this clinical trial is to learn about brain activity during walking adaptation in people with multiple sclerosis. Also, this clinical trial will test a form of nerve stimulation to see if it can improve walking performance.
The main questions it aims to answer are:
* What areas of the brain are the most active during walking adaptation?
* Can nerve stimulation make walking adaptation more effective?
Participants will walk on a treadmill where each leg will go a different speed which will create walking adaptation. At the same time, brain scans will occur. There will be two sessions of walking adaptation, one with nerve stimulation, and one without nerve stimulation. Researchers will compare people with multiple sclerosis to healthy young adults to see if there are differences in brain activity.
Who can participate
Age range
18 Years – 86 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* A diagnosis of relapsing remitting multiple sclerosis OR a neurotypical adult (ages 18-86)
* Not experiencing an active relapse
* Able to stand and walk without an assistive device
* Able to walk for three tenths of a mile without stopping to rest
Exclusion Criteria:
* Unable to walk for three tenths of a mile without assistance
* Musculoskeletal injury in past 6 months
* Lower extremity surgery in past 6 months
* Unable to abstain from medications that impair balance
* Currently pregnant
* History of traumatic brain injury
* History of vestibular disease
* History of any other balance impairment unrelated to multiple sclerosis
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Cortical Activation
Timeframe: Training session 1 (day 1), training session 2 (day 28)
2
Change in Adaptation Savings
Timeframe: Training session 1 (day 1), training session 2 (day 28)