Evaluation of Effectiveness of Combining High Protein Intake With Early Physical Exercise During Critical Illness

Inclusion Criteria: * Patients in age group 18-60 years * Expected Intensive Care Unit stay \>4days after enrolment (to permit adequate exposure to the proposed intervention) * Previously healthy, Well-nourished, subjects (nutric score=0) Exclusion Criteria: * Renal, liver or heart disease or chronic obstructive pulmonary disease * Previous immune abnormalities (including treatment with corticosteroids) * Past history of nutritional problems, chronic use of drugs (as drugs inducing myopathies) or orthopedic problems (such as skeletal fractures or immobilization) in the previous 2 years * Neuromuscular diseases and patients with amputated lower limbs * Past or recent history of cancer * Long term critically ill patients shifted from other hospitals * Pregnant patients