CompletedNot Applicable

GLP-1 Receptor Agonist Use and Incidence of Retained Gastric Food on Endoscopy

United States260 participantsStarted 2023-08-21

Plain-language summary

This study will enroll patients ages 18 and over who are in one of the following groups 1) taking a GLP-1 receptor agonist medication 2) not taking a GLP-1 receptor agonist (control group), are undergoing EGS and have appropriately fasted. Study data will be collected in the form of qualitatively observing whether the stomach is empty as expected, or contains solid or clinically relevant liquid contents.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria * Adults 18 years of age and older presenting for esophagogastroduodenoscopy (EGD) * One of the following groups: * GLP-1 receptor agonist cohort: active treatment with any GLP-1 receptor agonist therapy within prior 30 days * Control cohort: not taking a GLP-1 receptor agonist medication * Appropriately fasted per ASA Fasting Guidelines Exclusion Criteria * Simultaneous bowel preparation/planned dual endoscopy with colonoscopy * Any pre-planned alteration to standard fasting guidelines (ASA NPO guidelines) * Emergency endoscopic procedure * Concern for active GI bleeding * Food impaction/foreign body as indication for procedure * Gastric outlet obstruction/bowel obstruction * Achalasia * Zenker's diverticulum * History of esophageal or gastric surgery * Active pregnancy * Chronic daily opioid therapy ≥ 15 MMEs per day * Prokinetic agent use (i.e. metoclopramide) * Inability or unwillingness of subject to give informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Retained gastric food

Timeframe: From time of enrollment until the end of surgery, assessed up to 4 weeks

Trial details

NCT IDNCT05875636

SponsorMedical University of South Carolina

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-23

View on ClinicalTrials.gov More Gastric Content Aspiration trials