The aim of the present "OLFO-FOOD" clinical trial is to investigate, if olfactory stimulation impacts food choice, reference and calorie intake in humans with obesity assessed using a test buffet.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion Criteria:
* Age 18-60 years
* Written informed consent
* BMI ≥30 kg/m2
* Normosmia (as defined by Sniffin' Sticks Test)
Exclusion Criteria:
* Known allergy to olfactory stimulation substance, citrus fruits, citrus flavours, citrus food products
* Lactose-intolerance, celiac disease or non-celiac wheat sensitivity
* Diet other than omnivore or vegetarian
* Eating disorder (now or in the past)
* Dysphagia
* Acute disease affecting food intake
* Acute upper respiratory tract infection, acute or chronic sinusitis
* Severe visual impairment (vision \<10%)
* Surgical intervention of the nasal cavity or the paranasal sinus
* Current illicit drug abuse including daily marijuana and CBD (Cannabidiol) consumption (alcohol ≤2 drinks per day allowed)
* Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
* Type 1 and 2 diabetes mellitus
* Treatment with insulin-sensitizing drugs within the last 3 months
* Treatment with Glucagon-like Peptide 1 (GLP1)-analoga
* History of neurodegenerative diseases, severe head trauma
* Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2)
* Known liver cirrhosis or other severe liver impairment
* Use of any kind of decongestant more than twice a week
* Uncontrolled dysthyroidism
* Uncontrolled hypertension
* Regular use of psychopharmaceutic drugs
* Study participants aims to start a new diet or exercise program during the study
* Bariatric surgery
* Pregnancy/Lactation
* Inabilit…
What they're measuring
1
Change in calorie intake after olfactory stimulation
Timeframe: two time assessment at baseline and after 1 week