High tibial osteotomy (HTO) surgical procedure can lead to clinically significant improvements in the cartilage and in subchondral bone quality, with a slow down of the osteoarthritis (OA) progression. Aim of the project is to: (i) clinically validate a 3D planned HTO surgical approach, through a quantitative grading of OA progression in a prospective randomized case-control clinical trial; (ii) correlate the internal knee loads with the changes assessed in cartilage and subchondral bone status to verify the hypothesis that HTO induced mechanical changes are associated with clinically significant OA improvements; (iii) relate imaging data with cartilage and subchondral bone mechanical properties, in order to classify OA progression in a more sensitive manner and allow a more precise diagnosis of the pathology stage.
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Cartilage morphology and composition assessment via T1rho and T2 mapping from 3Tesla (3T) magnetic resonance imaging(MRI).
Timeframe: 3 years
Subchondral bone morphological and structural analysis via Cone Bean Computed Tomography (CBCT) of the knee.
Timeframe: 3 years
Clinical Score for Knee function 1
Timeframe: 3 years
Clinical Score for Knee function 2
Timeframe: 3 years
Clinical Score for Knee function 3
Timeframe: 3 years