Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome (NCT05865600) | Clinical Trial Compass
RecruitingNot Applicable
Perfusion Estimation For Optimal Treatment Strategy in Chronic Coronary Syndrome
Denmark570 participantsStarted 2023-05-23
Plain-language summary
We will establish a cohort of 570 symptomatic chronic coronary syndrome patients undergoing 15O-water PET and assess their symptoms through repeated questionnaires. Two hundred patients with abnormal perfusion will be randomized to immediate or delayed referral to invasive coronary angiography with concomitant optimization of guideline-directed medical therapy with repeated 15O-water PET and questionnaires at 3 and 6 months. The primary objective is to compare the potential benefit of early invasive coronary angiography (ICA) versus guideline directed medical therapy (GDMT) on symptomatic relief defined as freedom of angina after 3 months following a positive \[15O\]H2O cardiac PET/CT in patients with symptomatic chronic coronary syndrome.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age \> 18 years
✓. Willing to participate and able to understand, read and sign the informed consent document before the planned procedure
✓. Known ischemic heart disease defined as one of the following