Clinical Trial of Vit D and Calcium for Recurrent BPPV (NCT05863949) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Clinical Trial of Vit D and Calcium for Recurrent BPPV
860 participantsStarted 2025-08
Plain-language summary
Randomized double blind placebo controlled trial of vitamin D supplements, with or without calcium supplementation, versus placebo in reduction of recurrences in BPPV.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 years or older
* 2 or more distinct episodes of benign paroxysmal positional vertigo within a 12-month period on history
* At least 1 episode diagnosed based on physical examination by trained study personnel, meeting the diagnostic criteria of the Bárány Society
* Episodes separated in time, with a minimum of 1 week symptom-free between episodes
* Serum evidence of Vitamin D deficiency, as evidenced by 25-hydroxy vitamin D level of \<75 nmol/L (\<30 ng/mL)48
* Subject able to provide informed consent to participate in the study
Exclusion Criteria:
Potential subjects will be excluded if they
* have another identifiable cause of vertigo identified on history or physical examination
* have a history of allergy or medically significant adverse reaction to vitamin D or calcium carbonate
* have a chronic medical disorder which is a contraindication to vitamin D or calcium carbonate supplementation, including uncontrolled hyperparathyroidism, nephrolithiasis, or GI malabsorption disorders
* are on loop diuretic agents or thiazides
* have a contraindication to routine bloodwork for study purposes, including being hospitalized with a critical illness, cellulitis at blood draw sites, or presence of vascular grafts.