Persistent smell loss that can include diminished or distorted smell function is a common symptom of long COVID syndrome. There are limited treatment options for long COVID-related smell loss. This study aims to determine the efficacy of two at-home treatments, smell training and non-invasive trigeminal nerve stimulation. This study requires participants to conduct daily at-home treatment sessions, attend three in-person study visits at the MUSC Department of Psychiatry and Behavioral Sciences, and complete electronic questionnaires over the 12-week trial, and again at the six-month timepoint. Participants in this trial may benefit directly with an improvement in sense of smell. However, participation may also help society more generally, as this study will provide new information about long COVID-related smell loss and its treatment.
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Change in Psychophysical Olfactory Function from Baseline to 4 and 12 Weeks
Timeframe: 2 times: 4 weeks, 12 weeks
Change in Perceived Intensity of Odorants from Baseline to 4 and 12 Weeks
Timeframe: 2 times: 4 weeks, 12 weeks
Change in Perceived Hedonics of Odorants from Baseline to 4 and 12 Weeks
Timeframe: 2 times: 4 weeks, 12 weeks
Change in Olfactory-related Quality of Life from Baseline to 4 and 12 Weeks
Timeframe: 2 times: 4 weeks, 12 weeks
Change in Impact of Olfactory Loss from Baseline to 4 and 12 Weeks
Timeframe: 2 times: 4 weeks, 12 weeks