Active — Not RecruitingNot Applicable

Assessment of PaO2/FiO2 Ratio Pre and POst INTubation

United States, Spain400 participantsStarted 2023-04-29

Plain-language summary

We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients meeting criteria for AHRF while they are on non-invasive respiratory support. * We will only include patients who had arterial blood gases (ABG) within a time-frame of the last 5 hours of NIV and the first 5 hours of invasive MV. * We will only include patients treated with high-flow oxygen nasal cannula (HFNC), or continuous positive airway pressure (CPAP), or bilevel positive pressure (BiPAP). Exclusion Criteria: * Patients who never required HFNC, or CPAP, or BiPAP before intubation. * Patients with no ABG during the last 5 hours of NIV before intubation. * Patients with no ABG during the first 5 hours after initiation of invasive MV. * Patients treated with inhaled pulmonary vasodilator only before or only after intubation.

What they're measuring

Change in the degree of lung severity

Timeframe: 60 days

Trial details

NCT IDNCT05853068

SponsorDr. Negrin University Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-11-30