Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation of cytokine production (due to insulin resistance, excess visceral fat and hyperandrogenemia), i.e., overproduction of pro-inflammatory factors (e.g. TNF, IL-1, IL-6) in relation to anti-inflammatory ones (IL-10). This condition may be an important link between obesity and insulin resistance, which is crucial in the etiopathogenesis of the syndrome. However, it is not known whether it results from the tendency to accumulate adipose tissue or is a feature of the syndrome itself. Concomitant endocrinopathies, i.e. obesity, dyslipidemia, insulin resistance, diabetes and thyroid diseases, may additionally influence the activity of chronic inflammation. There is no data indicating the relationship between chronic inflammation and PCOS phenotypes, the severity of metabolic disorders, ovarian reserve and the influence of thyroid function on its activity in PCOS.
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Values of inflammation parameters - leukocytosis in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - CRP in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - procalcitonine in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - fibrinogen in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - ferritin in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - IL-1 in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - IL-6 in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - IL-10 in peripheral blood in both study arms
Timeframe: up to 6 months
Values of inflammation parameters - TNF-alpha in peripheral blood in both study arms
Timeframe: up to 6 months