Priming Motor Learning Through Exercise in People With Spinocerebellar Ataxia (NCT05826171) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Priming Motor Learning Through Exercise in People With Spinocerebellar Ataxia
United States20 participantsStarted 2023-02-06
Plain-language summary
PRIME-Ataxia is a randomized controlled trial that aims to determine the feasibility and efficacy of an 8-week telehealth intervention of high intensity aerobic exercise prior to balance training compared to an 8-week telehealth intervention of low intensity exercise prior to balance training in people with spinocerebellar ataxias (SCAs). The investigators additionally aim to explore changes in motor skill learning on a novel motor skill task in a sub-group of participants pre and post intervention.
Who can participate
Age range18 Years – 85 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Between the ages of 18 to 85 years
✓. Genetically confirmed diagnosis of SCA1, 2, 3, 6, and 7
✓. Scale for Ataxia Rating and Assessment (SARA) score between 8-25/40, capturing mild-moderate disease
✓. Able to walk with/without assistive device
✓. Successful completion of Physical Activity Readiness Questionnaire (PAR-Q) to confirm no medical contraindications to exercise
✓. Care partner availability during assessments and/or intervention pending balance scores
Exclusion criteria
✕. Severe non-ataxic motor symptoms such as dystonia, tremor, or Parkinsonism, measured by Inventory of Non-Ataxia Signs (INAS)
✕. Peripheral sensory loss (as confirmed with monofilament or clinical proprioceptive testing)
✕. Severe visual complications associated with ataxia (i.e., Spontaneous nystagmus, retinal or optic nerve involvement, especially in SCA7) defined as as have a score on the Snellen Visual Acuity test = 20/200 - 20/400, OR a visual field of 20 degrees of less.
What they're measuring
1
Change in Scale for Assessment and Rating for Ataxia
Timeframe: Baseline, Post-Intervention (4 months)
2
Change in Cerebellar Cognitive Affective Syndrome Scale
Timeframe: Baseline, Post-Intervention (4 months)
3
Change in Patient Reported Outcome Measure for Ataxia