Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers (NCT05823740) | Clinical Trial Compass
CompletedNot Applicable
Measuring Changes in Body Composition and Physical Function in Patients With Childhood Cancers
United States28 participantsStarted 2023-05-01
Plain-language summary
The primary objective of this study is to evaluate the feasibility and acceptability of obtaining repeated measurements of lean muscle mass, physical function, and biological aging in children receiving active cancer therapy. The secondary objective is to evaluate the feasibility of using the D3-creatine dilution method (D3Cr) to measure skeletal muscle mass in children with cancer.
Assessments will be collected at diagnosis, once during active treatment, and end of treatment in coordination with routine imaging to monitor changes in study outcomes during active cancer treatment. Key sociodemographic, treatment and health-related factors will be abstracted from the medical record.
Who can participate
Age range8 Years – 21 Years
SexALL
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Inclusion criteria
✓. Ages 8-21 years at the time of cancer diagnosis
✓. Must have a newly diagnosed malignant solid tumor or lymphoma.
✓. Participant is expected to undergo cancer treatment with either chemotherapy, radiation, immunotherapy, or other biologically targeted therapy.
✓. Participants will undergo routine imaging with either computed tomography (CT), or Magnetic Resonance Imaging (MRI) of the chest or abdomen, or whole-body positron emission tomography (PET) scan.
✓. Written informed consent obtained to participate in the study and HIPAA authorization for the release of personal health information.
✓. English or Spanish speaking
✓. Subject is willing and able to comply with study procedures.
✓. Since the patient is undergoing active cancer therapy, must obtain approval from the treating physician.
Exclusion criteria
✕. Prior history of cancer
What they're measuring
1
The feasibility of collecting body composition assessments
Timeframe: up to 12 months
2
The feasibility of collecting individual physical function assessments