The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).
Age range
12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Part 1: Geometric Mean (GM) of Omicron BA.4/5 at Day 29
Timeframe: Day 29
Part 1: Seroresponse Rate (SRR) Omicron BA.4/5 at Day 29
Timeframe: Day 29
Part 1: GM of the Ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) D614G at Day 29
Timeframe: Day 29
Part 1: SRR of Ancestral SARS-CoV-2 D641G at Day 29
Timeframe: Day 29
Part 1: Number of Participants With First Event of Centers for Disease Control and Prevention (CDC)-Defined COVID-19
Timeframe: From 14 days after injection up to Day 365
Part 1: Number of Participants With Solicited Local and Systemic Adverse Reactions (ARs)
Timeframe: Up to Day 7 (7-day follow-up after vaccination)
Part 3: Number of Participants With Solicited Local and Systemic ARs
Timeframe: Up to Day 7 (7-day follow-up after vaccination)
Part 1: Number of Participants With Unsolicited Adverse Events (AEs)
Timeframe: Up to Day 28 (28-day follow-up after vaccination)
Part 3: Number of Participants With Unsolicited AEs
Timeframe: Up to Day 28 (28-day follow-up after vaccination)
Part 1: Number of Participants With Any Serious AEs (SAEs), Medically Attended AEs (MAAEs), AEs Leading to Withdrawal From Study, and AEs of Special Interest (AESIs)
Timeframe: Day 1 up to Day 365
Part 3: Number of Participants With Any SAEs, MAAEs, AEs Leading to Withdrawal From Study, and AESIs
Timeframe: Day 1 up to Day 181