Intranasal Cocaine and Temperature Regulation During Exercise

Inclusion Criteria: * 18 to 50 years of age * Healthy * Body mass index less than 31 kg/m\^2 * Speak English * Systolic blood pressure \<140 mmHg * Diastolic blood pressure \<90 mmHg Exclusion Criteria: * Subjects not in the defined age range * Participants who have cardiac, respiratory, neurological, and/or metabolic illnesses * Any known history of renal or hepatic insufficiency/disease * Pregnancy or breast feeding * Body mass less than 60 kilograms * Current smokers, as well as individuals who regularly smoked within the past 3 years * Individuals with a history of drug abuse within the past 5 years * Individuals who have an unexplained positive urine drug screen (e.g., some agents cause false-positive results and when agent abstained the drug screen is negative, one example could be an over the counter supplement) * Currently taking pain modifying medications