[18F]FPIA PET-CT in Glioblastoma Multiforme (GBM)

Inclusion Criteria: Patients with histologically confirmed GBM following surgical resection of their tumour and are eligible for adjuvant chemoradiation with the following characteristics will be recruited: * Age ≥18 * World Health Organisation (WHO) performance status 0 - 2. * If female, the subject is either post-menopausal (at least 1 year), or surgically sterilized (has had a documented bilateral oophorectomy and/or documented hysterectomy for at least 2 years), or if of childbearing potential, must have a negative urine beta human chorionic gonadotropin (beta-HCG) pregnancy test done at initial screening and on the day of tracer administration. The result of the pregnancy test must be known before administration of 18F-FPIA injection. * The subject is able and willing to comply with study procedures, and signed and dated informed consent is obtained. * The subject has a satisfactory medical history as judged by the investigator with no significant co-morbidities, physical examination, and vital signs findings during the screening period (from 21 days before administration). * The subject's clinical and laboratory tests are within normal limits and/or considered clinically insignificant. Exclusion Criteria: * The subject has received any chemotherapy, immunotherapy, biologic therapy or investigational therapy within 14 days or five half-lives of a drug (whichever is longer) prior to the first dose of 18F-FPIA injection. * The subject is pregnant or lactating. * Any oth…