Lacticaseibacillus Rhamnosus CA15 (DSM 33960) Strain as a New Driver in Restoring the Normal Vaginal Microbiota

Inclusion Criteria: * Presence of at least one vaginal sign or symptom (leucorrhoea, burning, itching, subjective vaginal discomfort); * Presence of at least 3 Amsel criteria; * Nugent score greater than 7; * Lactobacillary grade greater than 2 (LBG) (according to Donders classification); * Vaginal dysbiosis based on microbial cell count. Exclusion Criteria: * Presence of sexually transmitted diseases due to Chlamydia, Neisseria gonorrhoeae or Trichomonas vaginalis as well as specific cervico-vaginitis or severe vulvovaginal symptoms related to acute candidiasis; * Clinically evident herpes simplex infection; * Human papillomavirus or human immunodeficiency virus infections; * Use of antibiotics, antifungals, probiotics, or immunosuppressants within the past four weeks; * Use of vaginal contraceptives and any other physiological or pathological condition that could potentially interfere with the results of the study (e.g. pregnancy or breastfeeding, chronic diseases, neoplastic diseases, diabetes, genital tract hemorrhages); * Enrollment in other programs that involve the administration of products that may affect the composition of the vaginal microbiota.