The goal of this clinical trial is to test the role of type H vessel and investigate the mechanism of its regulation in induced membrane created by induced membrane technique in patients with open fracture, aged between 20 and 80. The main questions to answer are: * Whether type H vessel will be critical for induced membrane-mediated bone healing? * Whether type H vessel will be a biomarker for diagnosing bone healing in patients with open fracture? * To find out a circulating indicator for type H vessel in patients with open fracture undergoing induced membrane technique. Participants will be enrolled to collect tissues of induced membrane and blood samples to detect type H vessel and measure the biomarkers of type H vessel, investigating their correlation with the capacity of bone healing. To avoid selection bias of treatment, the grouping will be achieved by a randomized protocol qualified clinical trial center of Chang Gung Memorial Hospital to divide into with induced membrane and without induced membrane. Researchers will compare these two groups to test our hypothesis that type H vessel in important in induced membrane and their corresponding biomarkers.
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The participants with open fracture will be assessed by the level of type H vessel
Timeframe: Induced membrane will be collected at 8th weeks of IMT performing procedures of stage II.
The participants with open fracture will be assessed by X-ray
Timeframe: Bone healing tracking will be up to 24 weeks after stage II operation.
The participants with open fracture will be assessed the metabolic alteration
Timeframe: Induced membrane will be collected at 8th weeks of IMT performing procedures of stage II. Blood will be a time-dependent manner through out this study up to 32 weeks.