Super Saturated Oxygen (SSO2) Therapy in Patients With ST-segment Elevation Myocardial Infarction (STEMI) and Action on Coronary Microcirculation Dysfunction

Inclusion Criteria: * Age \>18 years and \<80 years * ST-segment elevation myocardial infarction within 6 hours of symptom onset with ≥1 mm ST-segment elevation in ≥2 contiguous leads in V1-V4 or new left bundle branch block. * Successful PCI of a proximal or medial LAD lesion with commercially available coronary stents and achievement of residual stenosis \<50% diameter and thrombolysis-in-myocardial-infarction (TIMI) flow grade 2 or 3. * Systemic arterial pO2 greater than or equal to 10.7 kPa or 80 mmHg with or without oxygen supplementation. * Patient enrolled in a social security plan or beneficiary of such a plan * Consent obtained from the patient before inclusion (Emergency consent) Exclusion Criteria: * History of anterior coronary artery bypass grafting (CABG) * Previous myocardial infarction * History of PCI on the LAD * New LAD PCI planned within 30 days. * Mechanical complications of STEMI (Patients with ventricular pseudoaneurysm, ventricular septal defect (VSD), or severe mitral valve regurgitation (with or without papillary muscle rupture)), cardiogenic shock, or Presence of an intra-aortic counterpulsation balloon. * Valvular stenosis or heart failure, pericardial disease, or nonischemic cardiomyopathy. * Known prior left ventricular ejection fraction (LVEF) \< 40%, * Use of thrombolytic therapy * Patients with a contraindication to anticoagulant therapy. * Creatinine clearance \<30 ml/min/1.73 m2, * Hemoglobin \<10 g/dL * Gastrointestinal or urogenital ble…