The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies

Inclusion Criteria: * Age 18 years or over * diagnosis of breast cancer (Stage I-III or IV with minimal burden) and prescribed chemotherapy (TC (Docetaxel/Cyclophosphamide), AC (Doxorubicin/Cyclophosphamide followed by Paclitaxel), TCHP (Docetaxel, Carboplatin, Trastuzumab, Pertuzumab), TCH (Docetaxel/Carboplatin/Trastuzumab) with or without Pembrolizumab) * Physician clearance for exercise training * Speak/understand English Exclusion Criteria: * previous treatment with cardiotoxic chemotherapy * medical/orthopedic comorbidities that preclude stationary cycling * significant cardiac/renal/hepatic/hematological/pulmonary disease precluding exercise training * unstable angina or myocardial infarction within 4-weeks prior to treatment * complex ventricular arrhythmias or New York Heart Association class IV symptoms * symptomatic severe aortic stenosis * acute pulmonary embolus * acute myocarditis * History of untreated high-risk proliferative retinopathy * History of retinal hemorrhage * uncontrolled hypertension (systolic blood pressure \> 180 mm Hg or diastolic blood pressure \> 120 mm Hg) * severe baseline electrolyte abnormalities * medication non-compliance * uncontrolled metabolic disease (diabetes with fasting blood sugar \>300 mg/dl, thyrotoxicosis, myxedema) * symptomatic peripheral vascular disease * Pregnant women