Study to Evaluate the Pharmacokinetics (PK) and Safety/Tolerability of Long-Acting Oral LYN-005

Exclusion criteria

• . Participants with known clinically significant esophageal or gastrointestinal (GI) disease, including but not limited to:
• . Known strictures such as esophageal web, pyloric stenosis, or small intestinal stricture, or participants with high risk of stricture, eg, Crohn's disease.
• . Diagnosis of a condition known to elevate or lower gastric pH, eg, achlorhydria or hypochlorhydria.
• . Prior varices or small or large bowel obstructions.
• . Prior abdominal or upper gastrointestinal surgery (prior uncomplicated laparoscopic procedures including appendectomy or colectomy are permitted).
• . History of dysphagia or aspiration in the last 5 years.
• . History of an esophageal motility disorder or undergoing treatment for a gastric motility disorder.
• . Significant history of diarrhea or constipation within 3 months of Screening. For constipation, 2 or more of the following in the preceding 12 months (the episodes need not be consecutive): i. Straining \>1/4 of defecations; ii. Lumpy or hard stools \>1/4 of defecations; iii. Sensation of incomplete evacuation \>1/4 of defecations; iv. Sensation of anorectal obstruction/blockage \>1/4 of defecations; v .Manual maneuvers to facilitate \>1/4 of defecations (e.g., digital evacuation, support of the pelvic floor); vi.\<3 defecations per week; vii. Loose stools are not present, and there are insufficient criteria for irritable bowel syndrome.