Effects of Remote Ischemic Conditioning on Bimanual Skill Learning and Corticospinal Excitability… (NCT05777070) | Clinical Trial Compass
CompletedNot Applicable
Effects of Remote Ischemic Conditioning on Bimanual Skill Learning and Corticospinal Excitability in Children With Unilateral Cerebral Palsy
United States51 participantsStarted 2022-11-07
Plain-language summary
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The existing therapeutic interventions have higher training doses and modest effect sizes. Thus, there is a critical need to find an effective priming agent to enhance bimanual skill learning in children with UCP. This study aims to determine the effects of a novel priming agent, remote ischemic conditioning (RIC), when paired with bimanual skill training to enhance bimanual skill learning and to augment skill dependent plasticity in children with UCP.
Who can participate
Age range8 Years – 16 Years
SexALL
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Inclusion criteria
✓. Children diagnosed with unilateral cerebral palsy (UCP)
✓. Manual Ability Classification System (MACS) levels I-III
✓. Ability to complete a stack of 3 cups in 1 minute
✓. Mainstream in school
Exclusion criteria
✕. Children with other developmental disabilities such as autism, attention deficit hyperactivity disorder, developmental coordination disorders, etc.
✕. Children with absent active motor threshold
✕. Children with known cardiorespiratory, vascular, and metabolic disorders
✕. Children with neoplasm and hydrocephalus
✕. Children who are currently receiving or received other adjunct therapies such as rTMS and tDCS in the past 6 months
✕. Children with seizures within last 2 years and on anti-seizure medications
What they're measuring
1
Change in Bimanual Learning
Timeframe: Baseline and 1 week
2
Change in Symmetric performance and tangential velocities