Dietary Intervention to Reduce Metabolic Endotoxemia

Plain-language summary

The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and including nutrients related to antiinflammatory responses with an active control diet based on general healthy diet recommendations (CONV-D) in adults from 18 to 50 years of age with obesity (body mass index ≥30 kg/m2). The main questions it aims to answer are: * If the intervention with AIA-D will cause a significant decrease at the end of the intervention (six weeks) in lipopolysaccharide-binding protein (LBP) compared to CONV-D. * If intervention with AIA-D will cause a significant increase at the end of the intervention (six weeks) in the relative abundance of two specific bacteria genera (AM and FP) when compared to CONV-D. Participants will: * Sign the informed consent. * Provide two peripheral blood samples (taken by our trained professionals). * Provide two samples of feces. * Allow anthropometric (body weight, height, hip and waist circumferences) blood pressure measurements on two occasions. * Respond to 24 h dietary recall on two occasions. * Attend the 1-hour group sessions requested (three for AIA-D and one for CONV-D). * Follow the dietary recommendations provided. * Be willing to participate in social media groups to receive information and follow up during the six weeks of the intervention. Researchers will compare an antiinflammatory and environmentally friendly strategy (AIA-D) with an active control diet (CONV-D) based on general healthy diet recommendations to see if AIA-D decreases metabolic endotoxemia measured through LBP serum levels and increase the relative abundance of AM and FP, compared to CONV-D.

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Trial details