'Distress' refers to emotional distress, including psychological distress, in cancer patients. This study aims to explore whether mindfulness-based cognitive-behavioral therapy for cancer patients is effective in relieving distress and to discover neurophysiological factors that contribute to relieving distress. Mindfulness meditation, which is the core of mindfulness-based cognitive behavioral therapy, can develop cognitive flexibility through 'awareness of what is happening now'. In this study, a mindfulness-based cognitive behavioral therapy program is implemented for patients with advanced cancer, and clinical characteristics and conditions including distress level are observed through questionnaires and interviews. In addition, genetic data and brain imaging data are collected through blood sampling and brain magnetic resonance imaging. The ultimate goal of this study is to prove the therapeutic efficacy of a mindfulness-based cognitive behavioral therapy program for distress of patients with advanced cancer through an in-depth and multifaceted integrated approach, and to understand the related neurophysiological mechanisms.
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Distress level change
Timeframe: at baseline, 2nd week, 4th week, 8th week
Gray matter volume change
Timeframe: at baseline, 8th week
Gray matter thickness change
Timeframe: at baseline, 8th week
White matter microstructure change
Timeframe: at baseline, 8th week
Brain functional connectivity change
Timeframe: at baseline, 8th week
DNA methylation levels change
Timeframe: at baseline, 8th week