UnknownNot Applicable

Association Between PM2.5 Exposure and Ferroptosis in Seizures Patients

China60 participantsStarted 2022-12-01

Plain-language summary

This cohort study aims to discover the possible effects of PM2.5 exposures on the Nrf2- dependent ferroptosis pathway in seizure patients. This observational cohort's main question is whether PM2.5 exposures will affect the Nrf2- dependent ferroptosis pathway in seizure patients. Participants will be divided into two groups: the control group and the air pollution to detect the biomarkers of the Nrf2- dependent ferroptosis pathway in seizure patients

Who can participate

Age range6 Years – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Recently diagnosed with epilepsy (\< 2 months)
✓. living in this city for more than two years
✓. no exposure to any chemistry pollution before

Exclusion criteria

✕. abnormal IL-6 level before starting this pilot cohort
✕. other neurological disorders except for epilepsy;
✕. endocrine diseases;
✕. cancer
✕. receive anti-proinflammatory cytokines therapy

What they're measuring

The level changes of baseline IL6 three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days

The level changes of baseline 4HNE three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days

The level changes of baseline of mRNA expression of the Nrf2-dependent ferroptosis three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days

Trial details

NCT IDNCT05758129

SponsorAffiliated Hospital of Jiangnan University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2023-03-10

View on ClinicalTrials.gov More Exposure to Polluted Air trials

Plain-language summary

Who can participate

Age range6 Years – 18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Recently diagnosed with epilepsy (\< 2 months)
✓. living in this city for more than two years
✓. no exposure to any chemistry pollution before

Exclusion criteria

✕. abnormal IL-6 level before starting this pilot cohort
✕. other neurological disorders except for epilepsy;
✕. endocrine diseases;
✕. cancer
✕. receive anti-proinflammatory cytokines therapy

What they're measuring

The level changes of baseline IL6 three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days

The level changes of baseline 4HNE three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days

The level changes of baseline of mRNA expression of the Nrf2-dependent ferroptosis three months later

Timeframe: From the date of all participants documented baseline data, until the date of the last participant documented the changes of biomarkers in peripheral blood, assessed up to 90 days