Tegavivint for Treating Patients With Relapsed or Refractory Large B-Cell Lymphoma

Inclusion Criteria: One of the following three conditions: * Relapsed/refractory histologically confirmed germinal center B-cell-like (GCB) and non-GCB diffuse large B cell lymphoma (DLBCL) with the following features: * Increased expression of MYC (\>= 40%) and BCL2 (\>= 50%) by immunohistochemistry (IHC) or * Presence of isolated MYC translocation Or * Relapsed/refractory histologically confirmed high-grade B-cell lymphoma (HGBCL) (double hit \[DH\] and triple hit \[TH\]) with translocations of MYC and BCL2 and/or BCL6 Or * Histologic transformation of indolent non-Hodgkin's lymphoma (NHL) to DLBCL * Presence of BCL2 translocation with increased expression of MYC (≥40%) with or without MYC translocation * Patients must have had at least two prior systemic therapies * Patients must be ineligible for or refused autologous or allogenic hematopoietic stem cell transplantation or chimeric antigen receptor (CAR) T-cell therapy. Prior autologous stem cell transplant and/or CAR-T are allowed, if received \>= 3 months prior to enrollment * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Patients must have radiographically measurable disease by standard positron emission tomography (PET) uptake with at least one site of measured disease by standardized uptake value (SUV) * Absolute neutrophil count (ANC) ≥ 500/mcL * Platelet count ≥ 25,000/mcL * Total bilirubin =\< 1.5 x the upper limit of the normal range (ULN) * Aspartate aminotran…