UnknownNot Applicable

rTMS and Rehabilitation for Individuals With CRPS Type 1

United States20 participantsStarted 2023-02-28

Plain-language summary

Subjects with complex regional pain syndrome (CRPS) Type 1 will be randomized to receive repeated transcranial magnetic stimulation (rTMS) followed by rehabilitation or sham rTMS followed by rehabilitation. Treatment will last for 4 weeks, with the first week including 4 rTMS treatments and 2 rehabilitation treatments. Subsequent weeks will include 2 rTMS treatments followed by 2 rehabilitation treatments. Outcome measures will include pain ratings, PROMIS questionnaires, global rating of change, and grip strength or 1 repetition maximum leg press.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Upper or lower extremity CRPS Type 1 (also called RSD-Reflex Sympathetic Dystrophy) of at least 6 months. * Pain rating on NPRS of at least 4/10 * No initiation of a new intervention (i.e., medication, rehab, injections) in the previous 2 months. * No plan to initiate a new intervention during the study treatment timeframe (4 weeks). Exclusion Criteria: * A history of seizures or epilepsy * Intracranial metallic devices * Pacemaker * Intrathecal infusion pumps * Brain or spinal cord stimulators with epidural electrodes * Other ferromagnetic metallic intracranial implants * Apparent mental or psychiatric disorder that prevents adequate informed consent * Current pregnancy * Non-English speaking

What they're measuring

Numeric Pain Rating Scale (NPRS) Weekly Average

Timeframe: Sessions 1 (week 1), 4 (week 1), 6 (week 2), 8 (week 3), 10 (week 4). Surveys will also be sent at 4 weeks, 3 months, 6 months, and 1 year after last session.

Trial details

NCT IDNCT05745025

SponsorState University of New York - Upstate Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-01

Contact for this trial

Adam P Rufa, DPT, PhD

(315)464-6883 rufaa@upstate.edu